The Reds secured a thrilling 3-2 win over the Rossoneri at Anfield in the reverse fixture.
Jordan Henderson’s sublime effort was enough to put away the Italians, though they did have promising moments, which may give them confidence here.
Stefano Pioli’s side will look to win and hope that Porto, one point clear in second, do not take all three points at home to Atletico Madrid, who are tied with Milan on four points and also stand a chance of qualifying for the round of 16.
Here’s everything you need to know about the fixture at the San Siro in Milan:
When is it?
The game will kick-off at 8pm on Tuesday, 7 December at the Stadio Giuseppe Meazza, also known as the San Siro, Milan.
How can I watch?
The match will be available to watch on BT Sport 2, coverage starts at 7:45pm. Subscribers can stream the match via the BT Sport app.
AC Milan predicted XI: Maignan; Kalulu, Tomori, Romagnoli, Hernandez; Kessie, Tonali; Messias, Diaz, Krunic; Ibrahimovic
Liverpool XI: Alisson; Williams, Konate, Phillips, Tsimikas; Morton, Minamino, Oxlade-Chamberlain; Salah, Origi, Mane
AC Milan: 11/10
Liverpool will rotate heavily here, having already wrapped up top spot in Group B, and Milan are desperate for a result here to either secure third and a path to the Europa League or second ahead of Porto, who have a one point advantage over both the Italians and Atletico Madrid. We’ll lean towards a narrow home win given the desperation to qualify. 2-1.