PA Sport - Mon, 15 Mar 18:57:00 2010
The right-back limped out of Saturday's victory over Leeds in just the 15th minute after picking up a knock and he will face a late check.
Otsemobor was replaced by Wayne Thomas at St Mary's and he would be the likely candidate to fill in again should Otsemobor (pictured) not make it.
Lee Holmes is still struggling with a groin problem, but is not too far away from a return to action, while veteran full-back Graeme Murty is unlikely to play again this season after undergoing ankle surgery last month.
The Saints' victory over Leeds saw a return to winning ways after last week's defeat by Tranmere, but a late surge for the play-offs remains unlikely as they remain 16 points adrift of the top six.
Swindon boss Danny Wilson has a host of injury problems ahead of the trip to Southampton.
David Lucas and Vincent Pericard are the latest to join a treatment room that has suddenly become packed to the rafters.
First-choice goalkeeper Lucas was forced off after just 12 minutes of Saturday's 1-0 win at Brighton with a hamstring injury and he is doubtful to feature at St Mary's. Striker Pericard also fell victim to a hamstring injury in the first half at the Withdean and is doubtful.
Fellow forward Billy Paynter missed out altogether due to a hamstring problem of his own, as did defender Sean Morrison (groin) and the pair definitely remain sidelined.
Right-back Kevin Amankwaah made the bench after yet another hamstring strain but, despite failing to play, aggravated the problem again and is also doubtful.
But, in a rare piece of good news for Wilson, winger Danny Ward trained on Monday following the head injury which forced him off at the weekend and he should be okay.