League Two - Broken ankle rules Parkes out until 2012
The 19-year-old, who spent two loan spells at the Pirelli Stadium last season before committing to a further six-month loan spell this summer, will return to Leicester to begin his recuperation.
Parkes was stretchered off in second-half stoppage-time and an X-ray after the game revealed the extent of the damage.
A statement on the Brewers' website read: "The on-loan defender will now return to parent club Leicester City and will undergo an operation before beginning his rehabilitation work.
"As yet there is no definite length of time that Parkes will be out for although it is thought to be unlikely he will return before his six-month loan deal comes to an end with the Brewers in January."