* Chardy sets up showdown with Argentine del Potro
* Federer to play American Fish in quarter-finals (Updates after Djokovic win, adds detail)
Olympic champion Andy Murray suffered a second pre-U.S. Open setback in as many weeks when he was knocked out of the Cincinnati Open in the third round on Thursday, losing 6-4 6-4 to France's Jeremy Chardy.
World number one Roger Federer, in contrast, needed just 62 minutes to get by 19-year-old Australian Bernard Tomic 6-2 6-4 and book his spot in the quarter-finals.
It was even easier for second seed Novak Djokovic who advanced after Nikolay Davydenko retired injured following a 6-0 first set that took just 33 minutes.
Murray, the defending champion who pulled out of last week's Toronto Masters with a knee injury after his opening match, never looked himself as he was broken in the seventh game of the first set by Chardy, who is in the draw as a lucky loser.
Neither player could hold serve in the opening five games of the second set but Chardy held firm to go up 4-2 and never looked back in the 98-minute match.
Chardy, ranked 38th, has been in good form of late, beating American Andy Roddick in the first round in Cincinnati after defeating compatriot and world number six Jo-Wilfried Tsonga in Toronto last week.
The 25-year-old took full advantage of Murray's less-than-potent serve and unforced errors to post his first win against the Scotsman in five attempts.
"I didn't serve particularly well. I got broken three times in the second set, which isn't good enough. I broke him a couple of times in the second," said Murray.
"I had a lot of close games on his serve in the first and second set and didn't convert enough chances, and, yeah, I didn't serve well enough."
Murray will head to the Aug. 27-Sept. 9 U.S. Open with just three hardcourt games under his belt since his Olympic triumph on the grass courts at the All England Club but he says he is not worried about lack of preparation before Flushing Meadows.
"I won't play any more matches. Going into the big tournaments, sometimes I've won tournaments in the buildup and it hasn't helped me and then this year Wimbledon I lost in the first round at Queen's and made the final there for the first time," said Murray.
"So it doesn't normally have that much bearing. But, you know, obviously I would have liked to have done a bit better this week."
Chardy will now face Argentine Juan Martin del Potro who fought past Serb Viktor Troicki 7-6 2-6 6-1.
Federer will face American Mardy Fish who defeated Czech Radek Stepanek 6-3 6-3 in a repeat of the 2010 final here.
"It's his kind of surface, he's at home in America and so I am going to have my hands full," Federer said of Fish.
Djokovic will face Croatian Marin Cilic who defeated Spain's Pablo Andujar 7-6 6-2 after a disappointingly short encounter with Davydenko.
"It's never nice to win like that, it was obvious that he had problems as he wasn't able to serve over 90 miles per hour," said the Serb.
Canada's Milos Raonic pulled off a surprise 6-4 2-6 6-2 win over Czech fifth seed Tomas Berdych. Raonic will face Switzerland's Stanislas Wawrinka who won 6-3 6-3 over Japan's Kei Nishikori.