(Recasts with City draw)
* Adam and Skrtel sent off
* Adebayor scores twice for Spurs
Manchester City squandered a two-goal lead to drop their first Premier League points of the season in a 2-2 draw at Fulham on Sunday and Liverpool suffered a 4-0 hammering at Tottenham Hotspur after having two players sent off.
Roberto Mancini's side seemed set to make it five wins from five as two Sergio Aguero goals put them in charge at Craven Cottage but Fulham had other ideas and hit back through Bobby Zamora and Danny Murphy.
Charlie Adam and Martin Skrtel were sent off for Liverpool in their heaviest league defeat since 2003. Tottenham cashed in on a woeful Liverpool display with Emmanuel Adebayor scoring twice and Luka Modric and Jermain Defoe getting one apiece.
City began the day level on 12 points with Manchester United who were playing at home to Chelsea on Sunday.
Tottenham's second victory of the season, after they lost their opening two matches, lifted them to 11th place with six points. Liverpool are eighth with seven points after a second successive league defeat.
Aguero took his Manchester City goal tally to eight since joining from Atletico Madrid -- firing the visitors ahead from a David Silva pass after 18 minutes and then pouncing again immediately after the halftime interval.
Fulham replied when Zamora curled in a shot and Martin Jol's side earned a share of the points in the 75th minute when Murphy's shot deflected into the net off Vincent Kompany.
"It's incredible, we lost two points after we scored two goals and dominated the game, but I think this can be a lesson for us. When we have the chances we should score," Mancini told the BBC.
Liverpool collected seven points from their opening three games but defeat at Stoke City last weekend halted their progress and Sunday's poor display will raise questions about their ability to challenge for a top-four finish after another average season last term.
Kenny Dalglish's side began sluggishly and fell behind when Modric produced a moment of pure class, smashing a right-foot shot into the top corner of the net after the ball came back off Defoe on the edge of the area.
Liverpool's afternoon took a turn for the worse when Adam, who had already been cautioned, caught Scott Parker with a lunge and was shown a red card after 28 minutes.
Tottenham failed to turn their domination into more goals until Skrtel was dismissed in the 63rd minute for a foul on Gareth Bale having already been booked.
After that it was one-way traffic with Defoe lashing a low shot past Pepe Reina and two minutes later Adebayor displayed clever feet to side-foot home after Reina failed to gather Defoe's low shot.
The Togo striker, who used to score regularly for Arsenal against Tottenham before moving to Manchester City, then further endeared himself to the White Hart Lane faithful with a powerful second goal from close range in stoppage time.