US Open - Little to encourage Federer or Nadal
Whilst neither of those losses can be considered massive upsets, Fish being an accomplished performer on hard courts and Berdych a two-time winner over Federer last year, there were worrying aspects to both losses for the Spaniard and the Swiss.
Nadal, who was knocked out in the second round in Montreal last week, does not like to make excuses and regularly downplays injuries, but whether his foot troubles are purely run of the mill blistering or a more serious problem, he does not appear to have the sharpness and pace that has been key to his game.
To add to that, he has two nasty burns on the fingers of his right hand from an accident in a restaurant earlier this week when he was given a hot plate that left him in agony.
Nadal's defeat to Fish may also have been influenced by a hectic Thursday in which he played a three and a half hour three-setter against compatriot Fernando Verdasco and then kept his commitment to play in the doubles competition.
Friday's loss aside, the dynamism that is central to Nadal's success is not there at the moment and he needs to find it in the next two weeks if he is to defend his title at Flushing Meadows.
"Sometimes you are playing well; sometimes you are playing worse. I am playing a little bit worse now than well, so I accept the loss and work hard - that's the only way to come back to my best level," said Nadal.
"My movement wasn't perfect, I made more mistakes than usual with the forehand. I have to play more inside the court, more aggressively," he said.
"I have a few things to improve if I want to be ready for New York. I am going to work on that. I don't know if I will be in perfect condition in New York, but for sure, I will try everything."
In contrast, Federer looked fresh and relaxed this week before coming unstuck against Berdych's big serve in a repeat of his losses to the Czech at Wimbledon and Miami last year.
There have been signs that the old Federer, the fluent and confident player who won with such elegant ease in his heyday, is not beyond the reach of the 30-year-old.
But if the Swiss is to recapture his old form in time he would surely expect to be doing better than a quarter-final in Cincinnati after a third round exit in Canada.
"Last week wasn't very good. I thought it was okay. It was nice to get back on the tour and getting some practice in with top guys and playing some matches," Federer said. "Now, I thought this week I was feeling much better.
"I thought I played really well against (Juan Martin) Del Potro and (James) Blake. Sure, close matches. It's a quick court, so you're not going to be coming out of this tournament feeling like you have the greatest rhythm in the world, especially with the guys I played against.
"But all in all I feel okay. I feel better now than I did in Montréal where it wasn't a very good match against (Jo-Wilfried)Tsonga. So at least I have three more matches under my belt.
"And physically I'm feeling perfect. That's at least the positive thing coming out of this tournament."