Villas-Boas opted to leave England internationals Frank Lampard and Ashley Cole out of his side for their 3-1 Champions League defeat at Napoli, a result which heightened speculation that the Portuguese may be on borrowed time at the London club.
Wilkins, who was surprisingly dismissed from his role as Carlo Ancelotti's right-hand man in November 2010, hopes Blues owner Roman Abramovich will give Villas-Boas time to succeed but thinks Ferguson's management of established stars such as Paul Scholes, Ryan Giggs and Rio Ferdinand while bringing through younger players is an example he should follow.
"It's very important that when Andre is dealing with the senior players that those discussions have to take place," Wilkins told Sky Sports News.
"You see how well Sir Alex Ferguson manages the likes of Scholes and Giggs and Ferdinand, he manages them magnificently well - not only the playing time but also as human beings.
"There has got to be conversation and if Andre is asking for their opinion, then he shouldn't be too shocked when the opinion comes back because they are very powerful and very strong personalities, these guys he's dealing with."