MK Dons host Brentford with injury problems mounting.
Manager Karl Robinson's squad will be stretched to the limit as five senior players miss out through injury.
Right-back James Tavernier (knee) and fellow defender Gary MacKenzie (neck) were already sidelined for the visit of Carlisle on Tuesday night.
Centre-half Mathias Kouo-Doumbe filled in for Tavernier but was forced off after 68 minutes with a groin injury. Midfielder Luke Chadwick then dropped into the back line but he too had to come off seven minutes later with a knee problem.
Striker Dean Bowditch is also nursing a groin injury following the Carlisle defeat.
Adam Chicksen is expected to return to the first team as cover in defence while midfielders Alan Smith and James O'Shea and striker Jabo Ibehre could also come into the reckoning for starting roles.