Pavlyuchenko has not started a Barclays Premier League game this season, but has enjoyed a run of appearances in the Europa League and was expected to lead the line in Tuesday's Group A clash against Greek side PAOK Salonika.
That was until the Russian clashed with young winger Townsend in training on Monday in an accident that means manager Harry Redknapp is likely to give Jermain Defoe a starting berth, when he would have liked to have rested the England star.
"There is no-one else really because Pav did his knee yesterday (Tuesday)," Redknapp said.
"It doesn't look very good. He just banged it on Andros Townsend's head. He slipped and hit Andros and it looks very swollen. It doesn't look great."