Liverpool must do without vastly improved midfielder Lucas Leiva, who has been ruled out for the rest of the season.
Lucas suffered a knee ligament injury in Tuesday night's 2-0 Carling Cup victory over Chelsea, and it represents a huge blow for the Reds with the Brazilian one of the stand-out performers so far in this Premier League season.
Kenny Dalglish immediately triggered a recall clause in 19-year-old Jonjo Shelvey's loan deal with Blackpool in response to Lucas being sidelined.
Leaders Manchester City boast an entirely clean bill of health, with even Owen Hargreaves back to fitness and celebrating by playing a full 79 minutes at the Emirates Stadium on Tuesday.
QPR have suffered a spate of injuries, and Neil Warnock will be sweating on the fitness of Armand Traore and Heidar Helguson ahead of their home clash with West Brom at the weekend.
Managerless Sunderland are also without six players, while Harry Redknapp is having to make do with having seven players on the sidelines.
But the worst affected side remain Bolton, who now have defender David Wheater out due to suspension in addition to the seven players Owen Coyle already does not have at his disposal.
Meanwhile, high-flying Newcastle are without the suspended Jonas Gutierrez for the home encounter with Chelsea after his red card at Old Trafford last weekend.