The young midfielder has not played for United since October due to an ankle injury but has stepped up his recovery during the week and could be back on the bench for the highly anticipated match at Old Trafford.
Liverpool must decide whether to start Luis Suarez, who is certain to face a hostile reception after he was banned for eight games for racially abusing Patrice Evra earlier in the season.
Suarez's suspension finished for Monday's 0-0 draw with Tottenham and he appeared as a second-half substitute at Anfield.
Elsewhere, the African Cup of Nations continues to make its presence felt with Ivory Coast reaching the final of the competition.
That means Didier Drogba and Salomon Kalou are absent as Chelsea visit Everton, Kolo and Yaya Toure are unavailable for league leaders Manchester City as they visit Aston Villa and Newcastle are deprived of Cheick Tiote when they play Spurs.