Evans missed the 1-0 defeat at the Etihad Stadium in a game which saw Welbeck suffer an ankle injury which led to him wearing a protective cast after the game.
At Old Trafford Ferguson's side will look to take the title initiative back after Vincent Kompany's goal gave City the advantage, albeit on goal difference.
Ferguson said: "He (Evans) has improved a little bit but (will) not (be fit) for Sunday."
On Welbeck, he added: "He is out. He got injured on Monday. Hopefully he will be ready for the Sunderland game."
Meanwhile, City are at full strength when they visit Newcastle United on Sunday.
Newcastle expect key midfielder Cheick Tiote to be fit despite suffering a nasty facial injury in the 2-0 win over Chelsea on Wednesday night.
The table below has full club-by-club details of the weekend's injuries and suspensions.
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