Barcelona's Argentinian forward Lionel Messi reacts during the Spanish league football match Valladolid vs FC Barcelona …
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Cristiano Ronaldo, the leading scorer in Spain this season, took his tally to 24 goals when he headed the opener from Angel Di Maria's corner in the 11th minute and Marcelo added a second from Ronaldo's assist four minutes after the break.
David Navarro was harshly shown a straight red card in the 64th minute for an innocuous-looking tackle on Ronaldo and fellow Levante defender Nikos Karampelas put the ball into his own net nine minutes from time.
Real, unbeaten in 29 matches in all competitions, have 67 points with 11 matches left, with Atletico Madrid three behind in second after they won 2-0 at Celta Vigo on Saturday.
Champions Barca, who play at Real in the La Liga "Clasico" in two weeks time, turned in one of their worst performances of the campaign at Valladolid, who are battling relegation, and slipped to third on 63 points.
Bayern Munich continued their march towards the Bundesliga title in spectacular fashion with a 6-1 demolition of Wolfsburg that also led them to set a league record with their 16th successive win.
Thomas Mueller and Mario Mandzukic scored two goals each as Bayern exploded in the second half with a five-goal 17-minute spell that saw them protect their massive 20-point lead at the top with 10 games left to play.
Injury-plagued Borussia Dortmund were far less convincing but edged past Freiburg 1-0 courtesy of captain Sebastian Kehl's first goal in almost two years to go four points clear in second place.
Bayer Leverkusen drew 1-1 at Hanover 96 to remain third with Schalke, 4-0 winners over Hoffenheim thanks to a Klaas-Jan Huntelaar hat-trick, joining them on 44 points.
Juve have won all 14 home games, although it was a close call as Fiorentina substitute Ryder Matos headed against the crossbar with 10 minutes to go.
Juventus have 72 points from 27 games, 14 clear of second-placed AS Roma who were beaten 1-0 by a late Jose Callejon goal at third-placed Napoli. Napoli are on 55 points.
Zlatan Ibrahimovic was again the chief tormentor as French champions Paris St Germain won 3-0 at Bastia to stay eight points clear at top of the Ligue 1.
Ibrahimovic headed into the top corner in the sixth minute before his clever backheel set up Ezequiel Lavezzi for the second goal 13 minutes later. The Sweden international set up Lavezzi again for the third two minutes from time.
The result put PSG on 67 points from 28 games. Second-placed Monaco beat second-bottom Sochaux 2-1.
Olympiacos Piraeus's hopes of clinching a 41st Super League title were put on hold for at least one more week after they were beaten 2-1 by PAOK Salonica.
A week after suffering their first league defeat of the season, a 3-0 loss to Panathinaikos, the Reds put in another poor performance.
Greece left back Giorgos Tzavellas scored PAOK's winner from long range six minutes from the end. The result left PAOK and Atromitos tied in second place, 16 points behind Olympiakos, with six matches left.
Goals by Luisao and Rodrigo helped leaders Benfica to record their fifth league win in a row with a 2-0 win over Estoril.
Benfica, who have 55 points from 22 games, moved seven clear of Sporting, who drew 2-2 at Vitoria Setubal after both teams converted penalties in the last five minutes.
Third-placed Porto beat Arouca 4-1, helped by two goals from Ricardo Quaresma.
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