One of the producers on the show, a huge Blackpool fan, set the conundrum clue as 'PNE CRISIS' in a dig at their rivals who have recently been relegated from the Championship.
It comes just days after Blackpool fans managed to fly two banners taunting Preston over their relegation above North End's Deepdale ground during their final match of the season.
Last season Preston fans started the 'war' by infamously hanging a banner saying 'forever in our shadow' on the M55 as Blackpool fans travelled down to watch their Championship play-off final with Cardiff City.
Preston manager Phil Brown said the flown banners were "distasteful" and added "if I had a gun I would have shot the plane down" - but the club has taken the Countdown prank in better humour.
"We can see the funny side of the joke and accept that with any setback you will always have opposition supporters ready to poke fun," they said in a statement.
"If this is the handywork of somebody who supports a rival, then we will begrudgingly accept that it's a novel way of trying to do so. Most of the jibes are water off a duck's back to our supporters who are purchasing season tickets as we look forward to a hopefully successful season."
A Channel 4 statement said: "One of the members of the production team is a life-long Blackpool fan and it was intended to be friendly banter, all done in good humour."
Contestants had 30 seconds to guess the conundrum anagram with the answer in this case being 'Priciness'.
Blackpool are Preston's fierce rivals, and while North End prepare for life in England's third tier, Blackpool are currently battling to stay in the Premier League.