But now the veteran striker - who still turns out for Juventus at the age of 37 - has become even more famous in his homeland after he apparently brought a 12-year-old girl out of a coma.
Italian schoolgirl Giada Scalise suffered a brain hameorrhage on January 22 while watching her beloved Juve on TV at her home in the southern city of Crotone.
She lapsed into a coma, and after several weeks of making no progress her parents got in touch with the prolific striker to ask for his help.
Del Piero happily obliged by sending a recorded message, which was played repeatedly at Giada's bedside: "Hello Giada, this is Alessandro del Piero. I hope you'll wake up and come back to us as soon as possible to watch many of our games."
Within days Giada began to stir, and she was soon speaking again and even demanding ice cream to help her recuperation. Her dad, Francesco, is convinced that the star's intervention was the key to his daughter regaining consciousness.