Those who won their group do not have to worry about this stage, having received a bye straight through to the last-16, with Arsenal sailing through.
United, though, will have to play those extra two matches in February after they finished behind Real Sociedad on goal difference. Monaco and Roma are also teams Champions League sides will hope to avoid.
The eight runners-up from the Europa League will face a side dropping down from the Champions League, with Barcelona, Juventus, Ajax and Sevilla among them.
Here are all the details for today’s draw...
When is the Europa League draw?
The Europa League draw takes place on Monday November 7, 2022 at 12pm GMT.
UEFA’s headerquarters in Nyon, Switzerland will host the ceremony.
Teams qualified for Europa League draw
Those dropping down from the Champions League will be unseeded for the draw, while teams from the same country cannot be drawn against each other.
Europa League runners-up: Manchester United, Midtjylland, Nantes, Monaco, PSV, Rennes, Roma, Union Berlin.
Champions League third-placed teams: Ajax, Barcelona, Bayer Leverkusen, Sevilla, Sporting, Juventus, Salzburg, Shakhtar.
Where to watch the Europa League draw
TV channel: In the UK, the draw will be broadcast live on BT Sport 1.
Live stream: Uefa will show the draw via their YouTube channel while BT Sport subscribers can watch on the BT Sport website and app.
Live blog: You can follow it in full via Standard Sport’s live blog.
When will the Europa League knockout round matches take place?
The first legs will take place on February 16, 2023, with the return fixtures a week later on February 23.
The eight teams that win their ties will go through to the last 16, joined by the Europa League group winners.