Manchester United will face Newcastle United at Wembley Stadium on February 26 to contest the first major domestic trophy of the season, the Carabao Cup.
Italy have never beaten England and the English are obvious favourites for this tie which, will be Steve Borthwick's second match at Twickenham as head coach.
Usman Khawaja's trip from Australia to India was a delayed one, but he is "raring to go" ahead of the first Test starting on Thursday.
France and Ireland entered the 2023 Six Nations as the favourites and their showdown in the second round of fixtures could decide who wins a grand slam, after both sides won their opening games – against Italy and Wales respectively.