Italy have never beaten England and the English are obvious favourites for this tie which, will be Steve Borthwick's second match at Twickenham as head coach.
This year's Calcutta Cup opens the Six Nations Championship for England and Scotland.
Following today’s racing tips? In need of some guidance? Or just fancy a flutter?
Victory at home against Scotland was a bright spot for Wales in a below-par Six Nations performance last year, but a trip to Murrayfield is a different prospect entirely.