The Cincinnati Bengals beat the Kansas City Chiefs last year and will look to repeat the feat against a half-fit Patrick Mahomes.
RFU chief executive Bill Sweeney is potentially facing a no confidence vote from grassroots clubs.
Brock Purdy will aim to have Christian McCaffrey and Deebo Samuel both on the field as he bids to lead the 49ers to victory over the Eagles.
The Rugby Football Union has issued a humiliating apology for the distress caused by its plan to lower the tackle height for the community game but the governing body will not U-turn on its decision.