Liam Scales’ first senior international goal had dragged Ireland back into it.
Vangelis Pavlidis scored a stoppage-time winner for the Greeks.
Once-mighty Ghana plunged deeper into trouble in 2025 Africa Cup of Nations qualifying on Thursday when held 0-0 at home by Sudan in Accra. Since reaching the 2017 Cup of Nations semi-finals, Ghana have been on a downward trajectory, losing in the round of 16 two years later then twice being eliminated after the group stage.