Back in February, Kepa Arrizabalaga’s skied spot kick at Wembley handed the Reds their ninth crown in the competition, a new record that they will look to extend this campaign.
First up are League One side Derby, who last won at Anfield almost 24 years to the day of this third-round encounter.
Relegated last year amid massive financial turmoil, the Rams head to Merseyside off the back of an FA Cup draw with non-league Torquay.
Here are all the details for the game...
Date, kick-off time and venue
Liverpool vs Derby is scheduled for an 8pm GMT kick-off tonight, Wednesday November 9, 2022.
Anfield will host the match.
Where to watch Liverpool vs Derby
TV channel and live stream: The match will not be broadcast live on TV in the UK.
Liverpool vs Derby team news
Liverpool XI: Kelleher, Ramsay, Phillips, Gomez, Tsimikas, Bajcetic, Oxlade-Chamberlain, Clark, Frauendorf, Carvalho, Stewart.
Derby XI: Wildsmith, Forsyth, Hourihane, Cashin, Bird, Collins, Mendez-Laing, Smith, Roberts, Sibley, Osula.
Liverpool vs Derby prediction
Even with the expected rotations, the Reds should have too much for a side sat seventh in League One.
A 3-1 Liverpool win.
Head to head (h2h) history and results
Ragnar Klavan and Philippe Coutinho scored in their last meeting, a 3-0 Liverpool win at Pride Park in this competition.
Liverpool wins: 71
Derby wins: 35
Liverpool vs Derby match odds
Odds via Betfair (subject to change).