The Rams head to Anfield as huge underdogs but the hosts are in the midst of a hugely busy run of games and come into the fixture off the back of being pushed to the limit by Tottenham.
A number of long-term injury absentees are again unavailable for Liverpool, including Luis Diaz (knee), Joel Matip (calf), Arthur Melo (thigh) and Diogo Jota (calf).
James Milner (concussion) also misses out will not return until the weekend at the earliest.
Klopp turns to a number of reserve and young players for the third-round tie.
Caoimhin Kelleher starts in goal and there is a full debut for young Calvin Ramsay at right-back.
Alex Oxlade-Chamberlain, Kostas Tsimikas and Fabio Carvalho are also all in from the off, having been on the bench at Spurs.
Other youngsters involved include Stefan Bajcetic, the 18-year-old defensive midfielder who has featured four times already this season, and Melkamu Frauendorf.
Liverpool XI: Kelleher, Ramsay, Gomez, Phillips, Tsimikas, Bajcetic, Oxlade-Chamberlain, Clark, Frauendorf, Stewart, Carvalho
Subs: Adrian, Davies, Firmino, Elliott, Nunez, Doak, Cain, Quansah, Chambers