Pep Guardiola has decided against introducing a handful of young players to his starting line-up for the game but the decision at full-back has been made for him after Cancelo’s red card against Fulham.
A one-game ban will be served in midweek, opening up a spot for Sergio Gomez in the XI.
In terms of injuries, the visit of Chelsea is expected to come too soon for Kyle Walker (groin).
Rico Lewis starts in place of Walker at right-back after scoring against Sevilla in the Champions League.
Cole Palmer is in the XI but there is no spot for Josh Wilson-Esbrand, after both featured in the third round of last season’s Carabao Cup.
Erling Haaland, meanwhile, is fit for the bench having netted the late winner on the weekend following an ankle injury.
Manchester City XI: Ortega; Lewis, Dias, Laporte, Gomez; Palmer, Rodri, Gundogan; Mahrez, Alvarez, Grealish.
Subs: Ederson, Phillips, Stones, Ake, Haaland, De Bruyne, Bernardo, Akanji, Foden.