Losses
| Player | Losses |
|---|---|
| Cy Young | 316 |
| Pud Galvin | 305 |
| Nolan Ryan | 292 |
| Walter Johnson | 279 |
| Phil Niekro | 274 |
| Gaylord Perry | 265 |
| Don Sutton | 256 |
| Jack Powell | 256 |
| Eppa Rixey | 251 |
| Bert Blyleven | 250 |
| Robin Roberts | 245 |
| Warren Spahn | 245 |
| Steve Carlton | 244 |
| Early Wynn | 244 |
| Jim Kaat | 237 |
| Frank Tanana | 236 |
| Gus Weyhing | 234 |
| Tommy John | 231 |
| Bob Friend | 230 |
| Ted Lyons | 230 |
| Greg Maddux | 227 |
| Fergie Jenkins | 226 |
| Tim Keefe | 226 |
| Red Ruffing | 225 |
| Bobo Newsom | 222 |
| Jack Quinn | 218 |
| Sad Sam Jones | 217 |
| Chick Fraser | 216 |
| Charlie Hough | 216 |
| Tony Mullane | 214 |
| Mickey Welch | 214 |
| Jim McCormick | 214 |
| Red Faber | 213 |
| Burleigh Grimes | 212 |
| Paul Derringer | 212 |
| Jerry Koosman | 209 |
| Jamie Moyer | 209 |
| Pete Alexander | 208 |
| Vic Willis | 208 |
| Kid Nichols | 205 |
| Tom Seaver | 205 |
| Joe Niekro | 204 |
| Jim Whitney | 204 |
| Tom Glavine | 203 |
| Adonis Terry | 202 |
| George Mullin | 196 |
| Old Hoss Radbourn | 196 |
| Claude Osteen | 195 |
| Eddie Plank | 194 |
| Dennis Martinez | 193 |
| Rick Reuschel | 191 |
| Jerry Reuss | 191 |
| Mickey Lolich | 191 |
| Tom Zachary | 191 |
| Christy Mathewson | 188 |
| Bartolo Colon | 188 |
| Jack Morris | 186 |
| Mike Morgan | 186 |
| Mel Harder | 186 |
| Earl Whitehill | 185 |
| Roger Clemens | 184 |
| Jim Bunning | 184 |
| Al Orth | 184 |
| Joe Bush | 183 |
| Larry Jackson | 183 |
| Curt Simmons | 183 |
| Danny Darwin | 182 |
| Waite Hoyt | 182 |
| Hooks Dauss | 182 |
| Rick Wise | 181 |
| Murry Dickson | 181 |
| Dutch Leonard | 181 |
| Tim Wakefield | 180 |
| Lee Meadows | 180 |
| Dolf Luque | 179 |
| Wilbur Cooper | 178 |
| Rube Marquard | 177 |
| John Clarkson | 177 |
| Livan Hernandez | 177 |
| Mike Moore | 176 |
| Bill Dineen | 176 |
| Long Tom Hughes | 175 |
| Pink Hawley | 175 |
| Doyle Alexander | 174 |
| Jim Perry | 174 |
| Bob Gibson | 174 |
| Chuck Finley | 173 |
| Luis Tiant | 172 |
| Red Donahue | 172 |
| Red Ehret | 171 |
| Dennis Eckersley | 171 |
| Larry French | 171 |
| Camilo Pascual | 170 |
| Bert Cunningham | 170 |
| Billy Pierce | 169 |
| Jim Clancy | 167 |
| Red Ames | 167 |
| Amos Rusie | 167 |
| George Uhle | 166 |
| Howard Ehmke | 166 |
