| LF | 10-day-dl (The Houston Astros placed OF Chas McCormick on the 10-day injured list with right hamstring discomfort.) | |
| SS | 10-day-dl (The Houston Astros placed INF Grae Kessinger on the 10-day injured list.) | |
| P | 15-day-dl (The Houston Astros placed RHP Cristian Javier on the 15-day injured list with neck discomfort.) | |
| P | 60-day-dl (The Houston Astros placed RHP Lance McCullers on the 60-day injured list as he recovers from right elbow surgery.) | |
| P | 60-day-dl (The Houston Astros placed LHP Bennett Sousa on the 60-day injured list with left shoulder inflammation.) | |
| P | 60-day-dl (The Houston Astros transferred RHP Oliver Ortega from the 15-day injured list to the 60-day injured list.) | |
| P | 60-day-dl (The Houston Astros placed RHP Penn Murfee on the 60-day injured list as he recovers from right elbow surgery.) | |
| P | 60-day-dl (The Houston Astros placed RHP Luis Garcia on the 60-day injured list as he recovers from right elbow surgery.) | |
| P | 15-day-dl (The Houston Astros placed RHP José Urquidy on the 15-day injured list with a right forearm strain.) | |
| P | 60-day-dl (The Houston Astros placed RHP Kendall Graveman on the 60-day injured list.) | |