Carlos Alcaraz will miss the ATP Finals and the Davis Cup Finals after his season was cut short by an abdominal injury.
The world number one suffered an internal oblique muscle tear during a Paris Masters quarter-final against Holger Rune on Friday.
Alcaraz retired early in a second-set tie-break after losing the opening set 6-3 in the French capital.
The US Open champion on Saturday revealed it will take him six weeks to recover from the injury, so Taylor Fritz will take his place in the ATP Finals in Turin next week.
Teenager Alcaraz will also be unavailable for Spain's bid to win the Davis Cup on home soil, with the prestigious event getting under way on November 22 in Malaga.
He posted on Instagram: "After my withdrawal yesterday and having been evaluated by my medical team, Dr Juanjo Lopez and Juanjo Moreno, unfortunately this is the result of my injury: an internal oblique muscle tear in the left abdominal wall with an estimated recovery time of six weeks.
"Unfortunately I won't make the ATP Finals or the Davis Cup Finals. It is tough and painful for me to miss these two events, which are so important to me, but all I can do is be positive and focus on my recovery. Thank you for the support!"
The 19-year-old became the youngest player to top the ATP rankings after winning his maiden major title at Flushing Meadows in September and ends a magnificent season with a record of 57 wins and 13 defeats.
He has won five ATP Tour titles in 2022, with Masters 1000 triumphs in Miami and Madrid along with his finest hour in New York.