Wigan Warriors benefited from Kyle Amor's first-half dismissal as they took the bragging rights against arch-rivals St Helens, who suffered a 29-18 loss in the traditional Super League Good Friday clash and the first game since Keiron Cunningham's exit.
Saints parted company with head coach Cunningham on Monday, and the interim coaching team of Sean Long, Jamahl Lolesi and Derek Traynor saw their side reduced to 12 men inside just 13 minutes when prop Amor saw red for a high tackle on Liam Marshall.
The visitors took the lead six minutes later through Mark Percival's penalty, only for Wigan to capitalise on their extra man through Joel Burgess' 21st-minute score, with Morgan Escare converting that try and adding a further two points before the interval.
Morgan Knowles dummied his way over after the break to level matters for the undermanned Saints, who again responded after Marshall's try and an Escare drop goal had put Wigan seven points ahead as Regan Grace cut the gap to three.
But Wigan scored three unanswered tries through Liam Farrell, Marshall and Burgess, rendering Tommy Makinson's late score a mere consolation. Marshall's try was the pick of the bunch, the winger finishing a slick move with a stunning effort in the corner.
The Warriors' victory marked their first in five Super League games and moved them up to fourth, Saints remain eighth after three games without a win.
Leaders Castleford Tigers continued their rampant form, scoring six of their seven tries in the first half in a comfortable 42-24 win over Wakfield Trinity.
Jake Webster and Grant Millington each scored doubles in the opening 40 minutes as Castleford opened up a 36-12 half-time advantage that proved insurmountable for Wakefield.
Salford Red Devils are two points behind Castleford following a tight 12-6 triumph against Leigh Centurions, Gareth O'Brien scoring the decisive try 12 minutes from the end.
Leeds Rhinos are level with Salford on 14 points, bouncing back from their defeat to Warrington Wolves last time out by running in eight tries in a 52-24 rout of Hull FC.