Wyoming (2-0), which upset Texas Tech 35-34 in double-overtime at home in a season opener, faced Portland State (0-2) for the first time and put up 371 yards of offense while holding the Vikings scoreless for most of the second half.
Sam Scott ran for 70 of Wyoming's 170 yards.
Dante Chachere was 22-of-38 passing for 214 yards with a touchdown pass and a 2-yard scoring run.
After Wyoming turned the ball over with a fumble on its first possession, it scored on three of the next four possessions and led 21-10 at halftime.
AP college football: https://apnews.com/hub/college-football and https://apnews.com/hub/ap-top-25-college-football-poll