First, the Gunners must get past Sporting CP in their last-16 tie with the score level at 2-2 on aggregate ahead of Thursday’s meeting at Emirates Stadium.
Should they make it into the final eight, Arsenal will enter a draw that is completely open, meaning there will be no restrictions on which team they can face.
Manchester United could therefore be one possible opponent Mikel Arteta will want to avoid with the Red Devils currently 4-1 up on Real Betis in their tie.
Jose Mourinho has long been a foe for the Gunners and his Roma side are two goals up on Real Sociedad, the same scoreline Bayer Leverkusen lead Ferencvaros by.
The other two ties are all square as German dark horses Union Berlin head to Belgium to face Union Saint-Gilloise and Feyenoord take on Shakhtar Donetsk.
Possible Arsenal opponents in the Europa League quarter-final draw:
Manchester United or Real Betis
Feynoord or Shakhtar Donetsk
Sevilla or Fenerbahce
Union Berlin or Union Saint-Gilloise
Roma or Real Sociedad
Juventus or SC Freiburg
Ferencvaros or Bayer Leverkusen
The quarter-final ties will be held on April 13 and 20.