While the Gunners appear to be firing on all cylinders, Brighton head into the tie also full of confidence after beating Chelsea and Wolves in recent weeks.
Last season saw Mikel Arteta’s side fall at the semi-final stage but you have to go back to 1979 for the last time Brighton progressed into the latter stages of this competition.
Yet to meet in the league, tonight’s game provides a chance to see two of the country’s high-flying sides square off as they both eye a run to Wembley.
Here are all the details...
Date, kick-off time and venue
Arsenal vs Brighton is scheduled for a 7.45pm GMT kick-off tonight, Wednesday November 9, 2022.
The Emirates Stadium in London will host the match.
Where to watch Arsenal vs Brighton
TV channel and live stream: The game will not be broadcast live on TV in the UK.
Live blog: You can still follow all the action via Standard Sport’s live blog.
Arsenal vs Brighton team news
Arsenal XI: Hein; Cedric, Holding, Saliba, Tierney; Lokonga, Elneny, Vieira; Nelson, Nketiah, Marquinhos.
Subs: Turner, White, Gabriel, Zinchenko, Partey, Xhaka, Odegaard, Martinelli, Jesus
Brighton XI: Steel, Lamptey, Dunk, Colwill, Veltman, Caicedo, Gilmour, March, Sarmiento, Enciso, Welbeck
Substitutes: Sanchez, Webster, Gross, Undav, Mitoma, Ferguson, Estupinan, Turns, Moran
Arsenal vs Brighton prediction
Even with changed teams and a different atmosphere in this cup tie, the Gunners are firm favourites. Their reserves have been trotted out for Europa League action a number of times and will have a sharp edge on Brighton, should they choose to rotate.
A 2-0 Arsenal win.
Head to head (h2h) history and results
The last five meetings between these sides are evenly split at two wins apiece and a draw.
Arsenal wins: 14
Brighton wins: 6
Arsenal vs Brighton match odds
Odds via Betfair (subject to change).