Alex Oxlade-Chamberlain missed out with a hamstring injury, while Aaron Ramsey is recovering from a calf problem.
The Gunners find themselves nine-points off the top four following Saturday's results, and on a run of four defeats from their last five Premier League matches.
Speaking ahead of Sunday’s clash, Wenger reaffirmed his determination to continue in management.
Arsenal vs Manchester City team news
Arsenal starting XI: Ospina, Bellerin, Mustafi, Koscielny, Monreal, Xhaka, Coquelin, Walcott, Ozil, Sanchez, Welbeck
Substitutes: Martinez, Gibbs, Gabriel, Elneny, Maitland-Niles, Iwobi, Giroud
Manchester City starting XI: Caballero, Clichy, Stones, Otamendi, Fernandinho, De Bruyne, Sane, Silva (c), Sterling, Navas, Aguero
Substitutes: Bravo, Kompany, Zabaleta, Nolito, Kolarov, Delph, Yaya Toure
He said: "Retiring is for young people. For old people retirement is dying. I still watch every football game. I find it interesting."
"I carry a bit more pressure on my shoulders than 20 years ago (when he first arrived at Arsenal) but the hunger is exactly the same