The home team will aim to respond positively after their disappointing 3-0 loss to Liverpool in the Premier League last weekend, while Slavia Prague will seek to continue their impressive 21-match unbeaten streak.
The Czech top flight’s leaders have been reduced to 10 men in their last two games, though, and will be eager to avoid such disciplinary problems here as they face Premier League opponents in Europe for the second time this term.
Prague eliminated Leicester City in the last 32 – before knocking out Scottish champions Rangers in the last 16 – while Arsenal progressed against Olympiacos in the last round despite a second-leg loss.
Here’s everything you need to know about the quarter-final first leg this evening.
When is it?
The game will kick off at 8pm GMT tonight.
How can I watch it?
The match will air live on BT Sport, with subscribers also able to stream it live on the broadcaster’s website and app.
Arsenal: Leno; Bellerin, Holding, Gabriel, Cedric; Partey, Xhaka; Saka, Smith Rowe, Willian; Lacazette
Slavia Prague: Kolar; Bah, Zima, Holes, Boril; Hromada; Oscar, Stanciu, Provod, Olayinka; Sima
Arsenal certainly have the quality in their squad to pick up a home win here, but expect them to make hard work of this game against dangerous opponents. Arsenal 2-1 Prague.