Arteta recently indicated a January return for Emile Smith Rowe after groin surgery in September but the Newcastle match comes too soon for him.
Takehiro Tomiyasu is back from a hamstring injury but remains on the bench with Ben White the first-choice right-back.
Oleksandr Zinchenko has only just shaken off a problem but he keeps his place at left-back, with Kieran Tierney having to settle for a place on the bench again.
Eddie Nketiah continues up front, flanked by Bukayo Saka and Gabriel Martinelli.
Starting XI: Ramsdale, White, Saliba, Gabriel, Zinchenko, Xhaka, Partey, Odegaard, Saka, Martinelli, Nketiah.
Subs: Turner, Tierney, Holding, Tomiyasu, Vieira, Lokonga, Elneny, Marquinhos, Butler-Oyedeji.