Illness prevented the Brazilian forward from training on Wednesday and, despite hopes he could join the squad in the Netherlands, he joins the Gunners’ injury list.
As a result, manager Mikel Arteta goes with a front three of Eddie Nketiah, Gabriel Martinelli and Fabio Vieira as Arsenal look to get the point they need to win their group and get a bye through to the last 16.
“We had Marquinhos who wasn’t feeling well today and didn’t travel. For the rest we are okay,” said Arteta.
Matt Turner is due to start in goal again, and Rob Holding and Kieran Tierney should also come into the defence.
Albert Sambi Lokonga starts in midfield alongside Granit Xhaka and Martin Odegaard.
Confirmed team news
PSV: Benitez, Mwene, Ramalho, Branthwaite, Max, Veerman, Sangare, Gutierrez, Simons, El Ghazi, Gakpo
Subs: Hoever, Teze, Obispo, van Ginkel, de Jong, Madueke, Drommel, Junior, Til, Waterman, Bakayoko, Ledezma
Arsenal: Ramsdale, Tomiyasu, Holding, Saliba, Tierney, Odegaard, Xhaka, Sambi Lokonga, Vieira, Nketiah, Martinelli
Subs: White, Partey, Gabriel, Saka, Gabriel Jesus, Cedric, Nelson, Hein, Cirjan, Smith, Ibrahim