Ohuruogu came home fifth in the 400m as American Natasha Hastings took the line ahead of world silver medallist Amantle Montsho.
"I thought it would be quite nice to keep the momentum going and I knew I had some good runs still in me," said Ohuruogu, after clocking 50.95 seconds.
"But it's mentally tough and a bit harder to get back up after what has happened. But I did want to come out and run fast, but I wasn't quite sharp enough."
However, Martyn Rooney silenced the home crowd by claiming the scalp of Belgian favourite Jonathan Borlee in the men's 400m, clocking a season's best 45.05 secs.
"I'm really happy to win here. I've been ill for a week-and-a-half but to finish with a season's best, I'm happy with that," he said.
"It's a bit late in the season but gives me something to build on for next year."
World finalist James Dasaolu clocked 10.15 secs to come eighth in a 100m won by Usain Bolt in 9.80 secs, while British pair Chris Clarke and James Ellington were seventh and eighth respectively over 200m.
"For me it was about executing the start and I didn't do that as well as I would've liked to," said Dasaolu.
"I gave it my best, but maybe I was a bit distracted. When you look at my goals for the season I wanted to run sub-10 seconds, which I have done twice and I made the final in Russia."
Kenyan world champion Milcah Chemos won the women's 3,000m steeplechase as Eilish McColgan clocked her third fastest time ever, 9:15.06, to come eighth while Rhys Williams also finished eighth in the 400m hurdles and Andrew Osagie took the same position in the 800m, won in a world leading time by Mohammed Aman.
"I raced on Tuesday and ran a bit quicker. It has been a long season and everyone has tired legs," said Williams, after clocking 50.13 secs.
"I set myself high standards, I will have a few weeks off and then keep pushing on, determination is not an issue."
Elsewhere, world bronze medallist Tiffany Porter came fourth in the 100m hurdles while Hannah England avoided a mass pile-up in the 1500m to cross the line fifth - and admitted she could have done better.
"I felt really good with 500 metres to go but I had to jump over a lot of girls," she said. "I had to take a few steps on the inside so I didn't know if I was going to get disqualified.
"Some of the girls were trying to get out at the pack and I have no idea how I didn't fall over.
"I took a few steps on the inside, but I had no choice. It was either that or go down and it's a shame that's the last track of the season."
� Sportsbeat 2013
- Sports & Recreation
- Natasha Hastings