Diego Simeone's side have been struggling defensively, having conceded at least a goal in their last seven matches. It is the club's worst run without a clean sheet since Simeone's appointment a decade agao.
With one win in four games, Atletico lead at the top of La Liga was cut to three points, though with a game in hand.
So, what can Simeone do to stop a Chelsea team who have won five and drawn two of seven games under new manager Thomas Tuchel?
The defensive woes have coincided with Stefan Savic and Mario Hermoso being out injured - but they both return to the starting lineup tonight.
Up front, Luis Suarez is set to make things difficult for Chelsea despite his recent scoring drought in Europe's top competition.
Suarez has scored 16 times in his debut season with Atletico to propel them to the top of LaLiga, but he has yet to find the net in four Champions League games for the club.
"Luis generates fear in rivals no matter what competition it is," Simeone said. "He has skills and qualities that attract a lot of attention from any rival. We'll talk about his problems scoring away from home when we go to London, but tomorrow is a home game for us."
Atletico XI: Oblak, Llorente, Savic, Felipe, Hermoso, Correa, Koke, Saul, Lemar, Joao Felix, Luis Suarez
Subs: Grbic, San Roman, Kondogbia, Torreira, Renen Lodi, Dembele, Vitolo, Camello, Garcia, Sanchez
Atletico travelling squad: Grbic, Oblak, San Roman, Renan Lodi, Savic, Felipe, Hermoso, Alvaro G, Ricard, Kondogbia, Torreira, Koke, Saul, Lemar, M. Llorente, Vitolo, Joao Felix, Suarez, Correa, Dembele, Camello