The Wallabies defeated the reigning world champions 25-17 last weekend and are seeking a third victory in four matches in the highly-competitive four-team competition.
But all four sides involved - the other being Argentina - have lost in the opening three games, so it’s all to play for heading into this weekend.
Here’s all you need to know about Saturday’s fixture.
When is it?
The fixture will take place on Saturday 3 September at 10.35am BST.
How can I watch?
Fans in the UK can watch the game on Sky Sports Main Event or Sky Sports Arena. If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
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Australia have not made a single change to the side which edged out the Sprinboks last weekend.
Meanwhile, South Africa have swapped more than half their team out - making eight changes in total.
Australia: Hodge; Wright, Ikitau, Paisami, Koroibete; Lolesio, White; Slipper, Fainga’a, Alaalatoa, Arnold, Philip, Holloway, McReight, Valetini.
South Africa: Le Roux, Moodie, Kriel, De Allende, Mapimpi; Willemse, Hendrikse; Kitshoff, Marx, Malherbe, Etzebeth, De Jager, Kolisi (c), Mostert, Wiese.
Australia - 5/6
Draw - 20/1
South Africa - 21/20
Australia seem to have the edge over the world champions. They have beaten them in each of their last three meetings and will be confident they can extend that run in this one.35-20 Australia.