For the first time in 20 years, four or fewer of the top eight seeds in the men's singles will progress to the fourth round of the Australian Open.
Daniil Medvedev's defeat to Sebastian Korda on Friday meant he joined Casper Ruud, Taylor Fritz and defending champion Rafael Nadal in heading home early from the season's first grand slam.
According to Opta, it is the first time since 2003 that the round of 16 in Melbourne will include four or fewer of the top eight players in the competition.
Nine-time champion Novak Djokovic, meanwhile, is struggling with injury ahead of his third-round tie with Grigor Dimitrov on Saturday, while world number six and fifth seed Andrey Rublev faces a tough test against Dan Evans.
Stefanos Tsitsipas is sure of his place in round four after the Greek third seed beat Tallon Griekspoor in straight sets. Felix Auger-Aliassime will go up against Jiri Lehecka for a place in the last eight.