Nine-time champion Novak Djokovic will make his return to the Australian Open against Spain's world number 75 Roberto Carballes Baena.
After being deported from Australia last year amid a row over his refusal of a COVID-19 vaccination, Djokovic is firmly back in favour and chasing history in Melbourne, with a record-equalling 22nd men's singles grand slam in his sights.
He begins against an opponent who in four previous main draw appearances has only ever won one singles match at Melbourne Park.
Defending champion Rafael Nadal, whose 22 slam titles Djokovic is seeking to match, has a tricky opener against rising British star Jack Draper, the world number 40.
Second seed Casper Ruud will tackle Czech Tomas Machac first up, with the 115th-ranked player unlikely to prove too daunting an obstacle for last season's French Open and US Open runner-up.
Fifth seed Andrey Rublev could face an awkward assignment against wildcard and former US Open winner Dominic Thiem, while Australia's Nick Kyrgios begins against Russian Roman Safiullin.
Neither 13th seed Matteo Berrettini nor five-time runner-up Andy Murray would have been delighted to be paired together, but that is what happened in Thursday's draw.
In the women's singles, top seed Iga Swiatek starts her bid for a first Australian Open title against Germany's Jule Niemeier, who caught the eye last year on a run to the Wimbledon quarter-finals.
American seventh seed Coco Gauff starts against Czech Katerina Siniakova, while Jessica Pegula, Gauff's third-seeded compatriot who recently beat Swiatek in the United Cup, will face Belgian Jaqueline Cristian.
Gauff could face former US Open winner Emma Raducanu in the second round. Unseeded Briton Raducanu starts against Germany's Tamara Korpatsch.
Former champions Sofia Kenin and Victoria Azarenka go head to head in the first round, with American Kenin unseeded this year and Belarusian Azarenka the 24th seed.
Azarenka's compatriot Aryna Sabalenka is fancied to do well, having banished last year's serving yips, and the fifth seed starts against Czech Tereza Martincova.
Tunisian second seed Ons Jabeur, runner-up at Wimbledon and the US Open, begins her latest quest for an elusive grand slam title against Slovenian world number 88 Tamara Zidansek.
Former US Open winner Bianca Andreescu is unseeded in Australia and Czech 25th seed Marie Bouzkova drew a possible short straw by getting the Canadian in round one.