For the first time since 2005, the United States will be represented by three players in the men's singles quarter-finals of a grand slam.
Tommy Paul's win over world number 25 Roberto Bautista Agut on Monday ensured his place in the last eight, where he will face compatriot Ben Shelton.
With Sebastian Korda, who defeated Daniil Medvedev in round three, ticking off another top-10 opponent in the form of Hubert Hurkacz, the USA has three male players in the last eight of a major for the first time since the 2005 US Open, when Robby Ginepri, Andre Agassi and James Blake reached the quarters.
It is the first time the USA has had three representatives in the Australian Open quarter-finals since 2000, when Agassi, Pete Sampras and Chris Woodruff made it that far.
While Korda will face Karen Khachanov for a place in the semi-finals, Paul will go head-to-head with Shelton, the world number 89.
Shelton is the lowest-ranked American player to reach a major quarter-final in over 22 years, since Todd Martin at the US Open in 2000, and the lowest-ranked American to get so far in Melbourne since Michael Chang in 1996.
The 20-year-old has already beaten one compatriot, having defeated J.J. Wolff in a five-set thriller in his last match.
Meanwhile, it is the first time since 2006 that no Spanish male players will feature in the quarter-finals at the Australian Open.