Barca sit four points behind LaLiga leaders Real Madrid with four games left, and Real's superior head-to-head record means they would have to drop five points for Barca to stand any chance of winning the title.
Real's next game comes against Alaves on Friday, so Barca can temporarily close the gap to a point with a win at Camp Nou.
With kick-off at 9pm BST at Camp Nou, follow the action with Ben Hayward!
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Date, venue and kick-off time
Barcelona vs Espanyol will be held at Camp Nou on Wednesday, 8 June with a kick-off time of 9pm BST.
Prediction: Barcelona 4-0 Espanyol
Espanyol are rock-bottom of the table and Barca should make light work of their local opponents here.
How to watch
With games due to be shown on TV on Channel 435 on Sky, fans can also live stream the matches online via the Premier Player app.
Pre-match coverage will start at 8:15pm BST.
Barcelona XI: Ter Stegen, Semedo, Piqué, Lenglet, Jordi Alba, S. Roberto, Rakitic, Busquets, Suárez, Messi, Griezmann
Subs: Neto, Inaki Pena, Arthur, Braithwaite, Vidal, Riqui Puig, Collado, Ansu Fati, Araujo, Morer, Monchu, Cuenca
Espanyol XI: Diego López; Víctor G., Bernardo, Cabrera; Calero, Dídac, Pol Lozano, David López; Marc Roca, Embarba, Raúl de Tomás
Head to head (h2h) history and results
Espanyol held Barca to a 2-2 draw in the reverse fixture back in January, though Barca dominate this fixture historically with 123 wins to Espanyol's 44 in 211 derbies.
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