Los Blancos moved seven points clear of their arch-rivals on Sunday afternoon but to their credit, Barcelona responded well, travelling to fifth place Villarreal and putting four past the Yellow Submarine.
With Real not in action until Friday night, Barcelona have the chance to claw back some ground again.
Here’s how you can follow all the action...
Date, venue and kick-off time
Barcelona vs Espanyol will be held at Camp Nou on Wednesday, 8 June with a kick-off time of 9pm BST.
How to watch
With games due to be shown on TV on Channel 435 on Sky, fans can also live stream the matches online via the Premier Player app.
Pre-match coverage will start at 8:15pm BST.