Oklahoma City (17-4), who came into the game averaging more than 106 points, trailed the Pacers by four midway through the third quarter before seizing the momentum with a 17-3 run.
Kevin Durant scored 10 of his 27 points in the fourth quarter, while reserve Kevin Martin added 24.
David West had 21 points for the Pacers (10-11), who saw all of their starters reach double figures scoring.
With last season's leading scorer Danny Granger sidelined with a knee injury, Indiana averaged less than 91 points per game coming into Sunday's contest, which is last in the NBA.
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