A feast of Premier League derbies awaits this weekend, with bragging rights up for grabs from the rivalries in Manchester, north London and the Midlands.
Manchester City will be looking to hit back from a shock EFL Cup loss at Southampton as they head to Old Trafford to tackle an in-form United on Saturday.
Tottenham would love to jolt Arsenal's title assault when Mikel Arteta's side made the short trip across the capital on Sunday, while Nottingham Forest and Leicester City will be looking to edge a safe distance from the relegation zone when they clash at the City Ground.
Liverpool head to Brighton and Hove Albion, Everton host Southampton, Chelsea tackle Crystal Palace, and Newcastle United face Fulham.
Ahead of the latest round of matches, test your football expertise with our Opta-powered Premier League quiz. Answers are at the bottom.
1. In what season did Arsenal last complete a league double over north London derby rivals Tottenham, winning home and away?
2. Phil Foden scored a hat-trick in Manchester City's 6-3 win over Manchester United at the Etihad Stadium in October, but who was the last Englishman to score home and away for City against United in the same Premier League season?
3. Liverpool will be without the injured Virgil van Dijk in their game at Brighton, but they are unbeaten in their last 14 Premier League matches when the Dutchman has not started (W11 D3). Who were the last team to beat Liverpool when Van Dijk did not start for the Reds in the Premier League?
4. Southampton, who stunned Man City on Wednesday, have lost all four of their Premier League games under Nathan Jones so far, as they head to fellow strugglers Everton. Including caretaker bosses, only four managers have ever lost their first five games in charge in the competition. Who are they?
5. Leicester City's Jamie Vardy could make his first Premier League appearance since turning 36, having celebrated his birthday on Wednesday. Only four players aged 36 or over have played for the Foxes in the competition. Les Ferdinand, Marcin Wasilewski and Wes Morgan are three of those, but who is the other?
2. Shaun Wright-Phillips (2003-04 season)
3. Fulham (in March 2021)
4. Mick McCarthy (2003), Chris Hughton (1997-2010), Eric Black (2007-2016) and Scott Parker (2019).
5. Roberto Mancini