On Monday, it was widely reported that several teams were interested in a move for Hines, with the Colts heading into the second half of the season with a disappointing 3-4-1 record.
Buffalo then confirmed the trade in the final minutes before Tuesday's deadline, adding another offensive weapon for quarterback Josh Allen following a stellar start that has them top of the AFC with a 6-1 record.
In exchange, they have sent running back Zack Moss — a third-round pick in the 2020 draft — and a conditional 2023 sixth-round pick to the Colts.
A fourth-round pick in 2018, Hines has so far tallied 1,205 rushing yards and 10 rushing touchdowns, as well as 235 receptions on 300 targets for 1,725 receiving yards and seven touchdowns in his career.
Last season, Hines turned 15 of his 40 receptions into a first down while averaging seven yards after the catch per reception, and it is his receiving upside that the Bills will be looking to consistently harness as they aim to atone for the playoff heartbreak of the previous two seasons and end their wait for a first Super Bowl title.