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The 34-year-old Saffold joined Buffalo on a one-year contract in March after he was released by the Tennessee Titans following a 2021 season in which he earned his first Pro Bowl selection. The move saved Tennessee over $10million in salary cap space.
Saffold's setback was revealed as the Bills opened their training camp on Sunday.
McDermott said: "Rodger Saffold will start on the NFI list. Rodger injured some ribs in a car accident recently, so he'll start on NFI."
Saffold was the first pick in the second round of the 2010 NFL Draft by the St. Louis Rams. He spent his first nine seasons with the Rams before signing a four-year, $44million deal with the Titans in 2019.
Saffold’s 160 games since 2010 are tied for the fourth-most among active offensive linemen in the NFL over that span.
McDermott said he expected Saffold to "be back in due time".