Bills quarterback and MVP favourite Josh Allen ended up completing only 13 passes in the win, but that did not stop Diggs from enjoying a big day.
After a one-yard touchdown pass from Allen to tight end Dawson Knox gave the Bills a 7-0 lead at quarter-time, they doubled that advantage with the first play of the second quarter when Allen found Diggs streaking down the sideline with a 26-yard bullet.
Diggs helped the Bills add another three points in the final seconds of the first half when his 53-yard catch deep down the center of the field set up a field goal to make it 24-7 at the long break.
Packers quarterback Aaron Rodgers was determined to make a game of it, and he ended up completing touchdown passes to rookies Romeo Doubs and Samori Toure to trim the margin to 10 points with six minutes remaining.
But after two fourth-quarter interceptions from Allen, the Bills safely navigated the closing stages with a run-heavy, clock-chewing attack.
Allen completed 13-of-25 passes for 218 yards, two touchdowns and two interceptions, and nearly half of his total production went to Diggs, who collected six catches for 108 yards and a touchdown.
Both teams ran the ball well, with Devin Singletary (67 yards), James Cook (35 yards) and Allen (50 yards) combining for 152 yards for the Bills, while the Packers, led by Aaron Jones (143 yards on 20 carries), racked up 208 rushing yards.