Having put up 44 points in Monday's win over the Sacramento Kings, Booker continued his hot streak as the Suns secured a sixth victory on the bounce, downing the Bulls 132-113.
The Footprint Arena resonated with chants for Booker to land the MVP prize, and the 26-year-old was loving it.
"It's the best," Booker said about the home crowd.
"I don't know how many sell-out crowds that is in a row, but it's impressive.
"Mondays, Tuesdays, Saturdays, it doesn't matter what day of the week it is. They show up and show out."
Booker added 26 of his 51 points in the third quarter, including making five-of-five from three-point range.
It was the fourth 25-point quarter in Booker's career, tied with Kobe Bryant for second most in the past 25 years.
Booker shot at 80 per cent from the field, making six-of-seven from three-point range, while he also added four rebounds and six assists before sitting out most of the final quarter.
It marked Booker's fourth career 50-point game, which is the most in franchise history.
"It felt like a double-sized rim out there," Booker said. "If I rise up, it's going in."