Manchester United will face Celta Vigo in the semi-finals of the Europa League, while Ajax were paired with Lyon in Friday's draw.
United needed an extra-time winner from teenager Marcus Rashford to progress 3-2 on aggregate against Anderlecht, while Celta beat Genk to progress to the last four.
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The second leg will be played at Old Trafford.
In the other semi-final tie, knocking out Besiktas on penalties has earned Lyon the chance to take on Ajax, with the first leg to be played at the Amsterdam ArenA on May 4.
With the winners of the Europa League earning a qualifying spot in next season's Champions League, all four clubs will be keen to secure a place in the May 24 final at the Friends Arena in Solna, Sweden.