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Liverpool lost 1-0 at Leicester and City are looking to end 2021 with their 10th straight Premier League win.
Brentford are out to claim another big scalp, having already beaten Arsenal 2-0 and held Liverpool to a 3-3 draw at home this season.
City, however, are on a nine-game winning streak in the league and have scored 17 goals in their previous three matches.
Date, kick-off time and venue
Brentford vs Man City is scheduled for an 8.15pm GMT kick-off on Wednesday, December 29, 2021.
Brentford Community Stadium will host the first Premier League meeting between the two teams.
Where to watch Brentford vs Man City
TV channel: The match is exclusively available on Amazon Prime Video.
Live stream: Amazon Prime subscribers will be able to watch the match online via the Amazon Prime Video website or app.
Brentford vs Man City starting lineups and team news
Brentford XI: Fernandez, Pinnock, Jansson, Sorensen, Roerslev, Baptiste, Jensen, Onyeka, Thompson, Wissa, Toney.
Subs: Canos, Forss, Ghoddos, Peart-Harris, Bidstrup, Stevens, Cox.
Man City XI: Ederson, Cancelo, Dias, Laporte, Ake, Fernandinho (C), De Bruyne, Bernardo, Foden, Jesus, Grealish
Subs: Steffen, Carson, Sterling, Gundogan, Zinchenko, Mahrez, Mbete, Palmer
Brentford vs Man City prediction
Both teams will be impacted by injuries, Covid and fatigue which could serve to limit the breathlessness of the match. Still, City should have enough to see out a win.
Man City to win, 1-0.
Head to head (h2h) history and results
After losing to the Bees on Christmas Day 1937, City only won one meeting until 1989. Their last match came in the 1997 FA Cup third round.
Brentford wins: 5
Man City wins: 7